We are seeking a non-profit core facility that offers / could offer intact MS to help us and another group differentiate between MAb leads. Minimally, we would provide 10 to 50 purified MAbs / batch so we can choose ones with unique MWs to move forward and avoid working up the same MAb blindly multiple times. If the core could eventually also purify the MAb from media conditioned by the hybridoma, that would be ideal but that is not essential since we have this capability. We would likely have monthly batch submissions, but at times we could have batches a few weeks in a row, should you have that kind of bandwidth. Everyone on this ABRF Discussion Forum ... I hope you have a blessed and joyous holiday season ... and a much brighter 2023 than the last 2 years have afforded any of us ... Be well. Frances Head, Antibody and Bioresource Core Facility Memorial Sloan Kettering Cancer Center