On Thu, Nov 18, 2021 at 4:28 AM Susie <email obscured>> wrote:
> Do you have an automatic update function turning on for your mass spec PC?
> Can you turn it off? If you Google the cited language,people are taking
> about proxy settings. You may want to adjust that, but take careful notes
> for what you change d, so you can always change back.
>
> Not sure this helps or not. Unless the lab policy has requirements for LIMS
> and online data transfer, my approach for mass spectrometers is do not go
> to internet unless it is very necessary. Our IT folks don't like it, but I
> am able to bypass the IT folks that my mass spec does not need internet.
> When I need internet, we use wireless jump drives.
> I am not an individual who believes "ware" updates for mass spec. Many
> years ago, I lost my confidence after our GCMS service engineer convinced
> me to update my firmware when he was doing our PM. I ended up with losing
> all my methods and had to rebuild all of them.
> Susie
>
>
>
> On Wed, Nov 17, 2021, 5:42 PM Kym Faull <email obscured>> wrote:
>
> > > Dear Colleagues: We have a problem with our LC/MS QE instrument.
> Long
> > ago we had a problem with it in which every Thursday morning at the same
> > time the instrument would quit because of some glitch with the internet
> > connection. We concluded that a strange signal from the internet was
> > causing the instrument to quit. We implemented a work-around in which
> the
> > internet connection was disabled for the time around when this was
> > happening, and the connection was re-established after the elapsed time.
> > This work-around worked for a long time with occasional instances at
> other
> > times when the problem would sporadically pop-up. The situation has
> > recently changed. The hiccup is now occurring frequently. It has
> recently
> > occurred 10 times in 4 days. The error messages that are reported are
> > copied below. Of course we have been run touch with Thermo people, but
> so
> > far the problem has not been solved. Any and all advice about this will
> be
> > greatly appreciated.
> >
> > Kym
> >
> >
> > Kym Francis Faull, Ph.D.
> > Director, Pasarow Mass Spectrometry Laboratory
> > Jane and Terry Semel Institute for Neuroscience and Human Behavior at
> UCLA
> > Professor Emeritus on Recall, Department of Psychiatry and Biobehavioral
> > Sciences
> > David Geffen School of Medicine at UCLA
> > Telephone: (310) 206 7881 (office)
> > Telephone: (310) 206 7886 (laboratory)
> > Facsimile: (310) 206 2161
> > Electronic mail: <email obscured> <email obscured>>
> >
> >
> >
> >
> >
> >
> >
> >
> > > Begin forwarded message:
> > >
> > > From: Julian Whitelegge <email obscured>>
> > > Subject: Re: we need help
> > > Date: November 16, 2021 at 1:28:57 PM PST
> > > To: Kym Faull <email obscured>>
> > >
> > > Kym, Have you tried posting the error message on the ABRF site ? I
> can’t
> > believe we are the only ones with this problem... Julian
> > >
> > >> On Nov 16, 2021, at 1:26 PM, Kym Faull <email obscured> <mailto:
> > <email obscured>>> wrote:
> > >>
> > >> Kent: We have done everything you suggest and the problem still
> > occurs. Sometimes it occurs shortly after setting a worklist running,
> and
> > last weekend it ran uninterrupted from Friday until sometime on Sunday
> when
> > it quit. Attached below is the error message that appears when the
> > problems occurs. We don’t know what t o do next, Can you help us?
> Before
> > we request a visit from a service engineer I thought a ZOOM or WEbEX
> > “meeting” might be the next thing to try.
> > >>
> > >>
> > >> Kym
> > >>
> > >>
> > >>
> > >>> Begin forwarded message:
> > >>>
> > >>> From: whitaker cohn <email obscured> <email obscured>>>
> > >>> Subject: Fw: QE Error Message
> > >>> Date: November 11, 2021 at 9:03:33 AM PST
> > >>> To: Kym Faull <email obscured> <email obscured>>>
> > >>>
> > >>> The QE turned off again last night. These were the error messages at
> > the time of the event:
> > >>>
> > >>> -Info Service 18:40:20.142-07:00 on 2021-11-04 Starting
> > acquisition
> > >>>
> > >>> -Warning Service 19:49:55.603-07:00 on 2021-11-04 reading
> > data: A connection attempt failed because the connected party did not
> > properly respond after a period of time, or established connection failed
> > because connected host has failed to respond
> > >>>
> > >>> -Warning Service 19:49:57.069-07:00 on 2021-11-04 reading
> > data: A connection attempt failed because the connected party did not
> > properly respond after a period of time, or established connection failed
> > because connected host has failed to respond
> > >>>
> > >>> -Warning Service 19:49:57.132-07:00 on 2021-11-04 reading
> > data: A connection attempt failed because the connected party did not
> > properly respond after a period of time, or established connection failed
> > because connected host has failed to respond
> > >>>
> > >>> -Error Instrument 19:50:04.601-07:00 on 2021-11-04
> > [Inspect/Networking/Control handler] No network connection to data system
> > (s)
> > >>>
> > >>> I think we need to focus on remedying "A connection attempt failed
> > because the connected party did not properly respond after a period of
> > time, or established connection failed because connected host has failed
> to
> > respond". Not sure how to do this. Maybe Boston has some ideas.
> > >>>
> > >>> This also occurs when the instrument is not connected to the
> internet.
> > It would be great if these error messages could be shared among the
> Thermo
> > instrument technicians. Somebody has to have encountered this before...
> > >>>
> > >>> Sincerely,
> > >>> Whitaker
> > >>>
> > >>>
> > >>>
> > >>>
> > >>>
> > >>>
> > >>>
> > >>> Whitaker Cohn, B.S.
> > >>> Ph.D. Candidate
> > >>> Drug Discovery Lab
> > >>> Pasarow Mass Spectrometry Lab
> > >>> UCLA | Molecular, Cellular & Integrative Physiology Program
> > >>> (818) 268-5795
> > >>>
> > >>>
> > >>
> > >
> >
> >
> > ――
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> >
> >
>
> ――
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>